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このデータは、「メチル化をサポートする食事とライフスタイルの介入が、中年期および老年期の男女両方の生物学的年齢に好影響を与える可能性がある」ことを示唆しています。
8 週間のメチル化をサポートする食事とライフスタイル プログラムは、一連の女性の生物学的年齢を大幅に減少させることがわかっており、そのような介入は、病気による老化ではなく、老化の根底にあるメカニズムに影響を与え、男女ともに効果的である可能性があることを示唆しています。
ジャーナルに掲載された新しい研究論文 エージング 特別な食事/ライフスタイル プログラムの影響を調べます。
影響を与えることを目的とした、メチル化をサポートする食事とライフスタイルプログラムを受けた6人の女性のケースシリーズ[{” attribute=””>DNA methylation and measures of biological aging, was reported on by researchers Kara N. Fitzgerald, Tish Campbell, Suzanne Makarem, and Romilly Hodges. These researchers are associated with the Institute for Functional Medicine, Virginia Commonwealth University, and the American Nutrition Association.
“The modifiable lifestyle intervention used by participants in this case series was first investigated in a pilot clinical trial in which participants (all men between the ages of 50-72 years) reduced their biological age by an average of 3.23 years as compared to controls. The case series reported on herein was conducted to further the investigation of a modifiable lifestyle intervention that was largely the same in other populations; importantly in women.”
The team carried out an intervention consisting of an eight-week program. This program included guidance on diet, sleep, exercise, and relaxation, supplemental probiotics and phytonutrients, and nutritional coaching. DNA methylation and biological age analysis (Horvath DNAmAge clock (2013), normalized using the SeSAMe pipeline) were conducted on blood samples at baseline and at the end of the eight-week period.
Five of the six participants exhibited a biological age reduction of between 1.22 and 11.01 years from their baseline biological age. There was a statistically significant (p=.039) difference in the participants’ mean biological age before (55.83 years) and after (51.23 years) the 8-week diet and lifestyle intervention, with an average decrease of 4.60 years. The average chronological age at the start of the program was 57.9 years and all but one participant had a biological age younger than their chronological age at the start of the program, suggesting that biological age changes were unrelated to disease improvement and instead might be attributed to underlying aging mechanisms.
“This case series of women participants extends the previous pilot study of this intervention in men, indicating that favorable biological age changes may be achievable in both sexes. In addition, the investigation of otherwise-healthy individuals, rather than those with diagnosed disease, suggests an influence directly on underlying mechanisms of aging instead of disease-driven aging.”
Reference: “Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series” by Kara N. Fitzgerald, Tish Campbell, Suzanne Makarem and Romilly Hodges, 22 March 2023, Aging.
DOI: 10.18632/aging.204602
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